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Centre for Policy on Ageing | |
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Schizophrenia with onset after age 50 years
— 2. Neurological, neuropsychological and MRI investigation | | Author(s) | P Sachdev, H Brodaty, N Rose |
| Journal title | British Journal of Psychiatry, vol 175, November 1999 |
| Pages | pp 416-421 |
| Keywords | Schizophrenia. |
| Annotation | Late-onset schizophrenia LOS) may have a basis in age-related coarse brain disease, but empirical evidence for this is conflicting. The aim of this study was to investigate whether LOS is characterised by more neurological disease than early-onset schizophrenia (EOS). A total of 27 patients with LOS were compared with 30 patients with EOS and 34 control subjects on neurological status, neuropsychological test performance and brain magnetic resonance imaging (MRI). LOS and EOS groups had more `soft' neurological signs and drug-induced movement abnormalities, and performed more poorly on tests assessing speed of information processing, memory and frontal executive functioning. On MRI, the LOS and EOS groups had greater lateral ventricular size than the control group. The LOS subjects also had more MRI hyperintensities. (AKM). |
| Accession Number | CPA-991201226 A |
| Classmark | ELK |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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