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Centre for Policy on Ageing | |
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| Emerging issues in antibiotic resistant infections in long-term care facilities | | Author(s) | Robert A Bonomo, Louise B Rice |
| Journal title | The Journals of Gerontology Series A: Biological sciences and Medical Sciences, vol 54A, no 6, June 1999 |
| Pages | pp B260-267 |
| Keywords | Infectious diseases ; Drugs ; Public health ; Care homes ; Nursing homes ; General hospitals ; United States of America. |
| Annotation | Managing patients infected with antibiotic-resistant bacteria is becoming one of the major clinical obstacles facing doctors treating patients in long-term care. Penicillin-resistant pneumococci (PRP), vancomycin-resistant enterococci (VRE), germ-negative bacteria that produce extended-spectrum and ampC-type beta-lactamase enzymes, quinolone-resistant gram-positive and gram-negative bacteria are the major resistant pathogens emerging in these settings. The mechanisms responsible for the evolution of these antibiotic resistant organisms (molecular rearrangement of penicillin binding protein genes, acquisition of a mobile genetic element, and point mutation that alter the active site) are reviewed. Vancomycin intermediate Staphylococcus aureus (VISA) and multidrug efflux pumps in gram-negative bacteria are also threatening our most potent antimicrobials. Aggressive screening, education, antibiotic control measures, and immunisation are advocated as important preventive measures. The combined efforts of medical directors, infection control personnel and administrators are needed to stem this problem. (RH). |
| Accession Number | CPA-990825337 A |
| Classmark | CJA: LLD: RC: KW: LHB: LD3: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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