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Centre for Policy on Ageing | |
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| A view of the aging-disease relationship from age 85 | | Author(s) | Herman T Blumenthal |
| Journal title | The Journals of Gerontology Series A: Biological sciences and Medical Sciences, vol 54A, no 6, June 1999 |
| Pages | pp B255-259 |
| Keywords | Biological ageing ; Diseases ; Octogenarians ; Mathematical models. |
| Annotation | This essay posits a continuum between biological and pathological ageing based on four tenets. First, biological ageing is not genetically programmed. Second, both biological ageing and the diseases of the senescent period are caused by intrinsically generated random phenomena. Third, the same phenotypic disease can occur in the juvenile, mature, and senescent periods of the life span, but with genetic mutations having a progressively diminishing role with advancing age. Finally, the diseases of the juvenile period are of congenital or inherited origin, whereas those in maturity derive from late-acting genes or from so-called risk factors. During the senescent period, they derive from the same types of intrinsic random events that account for biological ageing. The author examines ageing-disease models, and the genotypes which cause dementias such as Alzheimer's disease (AD). (RH). |
| Accession Number | CPA-990825336 A |
| Classmark | BH: CJ: BBM: 3LM |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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