Centre for Policy on Ageing



Dynamic paradigms for human mortality and aging
Author(s)	Kenneth G Manton
Journal title	The Journals of Gerontology Series A: Biological sciences and Medical Sciences, vol 54A, no 6, June 1999
Pages	pp B247-254
Keywords	Biological ageing ; Longevity ; Death ; Mathematical models.
Annotation	Hazard models are often applied to mortality data of humans and other species so that parameter estimates made for those models can be used to make inferences about the biology, and comparative biology, of ageing processes. There is now enough longitudinal data on physiological and functional changes in humans to know that the age trajectory of people's physiological state is multi-dimensional, stochastic and plastic. In order to fully assess the biological significance of existing longitudinal data on human ageing and mortality processes, multivariate stochastic process models must be developed that are biologically detailed and valid. This requires assessing genetic mechanisms controlling human longevity and rates of ageing, developing models of how these traits may have evolved, and developing statistical methods for identifying gene environment interactions. This article examines the theoretical basis for such models and the biological rationale of their parametric structure. Some examples are given. (RH).
Accession Number	CPA-990825335 A
Classmark	BH: BGA: CW: 3LM
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...from the Ageinfo database published by Centre for Policy on Ageing.