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Centre for Policy on Ageing | |
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| Estrogen replacement therapy and cognitive decline in older community women | | Author(s) | Karen Matthews, Jane Cauley, Kristine Yaffe |
| Journal title | Journal of the American Geriatrics Society, vol 47, no 5, May 1999 |
| Pages | pp 518-523 |
| Keywords | Drugs ; Mental ageing ; Older women ; Living in the community ; Longitudinal surveys ; United States of America. |
| Annotation | History and current use of oral HRT (hormone replacement therapy) was documented for 9651 white US women aged 65+ enrolled in the Study of Osteoporotic Fractures. A Mini-Mental State Examination (MMSE) and Trails B tests were also administered twice, 4 to 6 years apart. Age, educational attainment and activity limitations were the primary covariates in the analyses; in addition, stroke and depression scores were adjusted in subsets of women with available data. Current and past users of HRT had better initial scores on MMSE than never-users, with better scores for current oestrogen hormone users apparent among older and less educated women. Educational attainment predicted both initial test scores and change scores, and was, next to age, the most powerful predictor of cognitive function. Current oral HRT does not protect against age-related declines in cognitive function in older non-demented women, whereas formal education does, even though it had been completed many years earlier. The influence of education in late-life on cognitive function should be tested. (RH). |
| Accession Number | CPA-990825301 A |
| Classmark | LLD: D6: BD: K4: 3J: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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