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Centre for Policy on Ageing | |
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| Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease | | Author(s) | Mark W Bondi, David P Salmon, Douglas Galasko |
| Journal title | Psychology and Aging, vol 14, no 2, June 1999 |
| Pages | pp 295-303 |
| Keywords | Dementia ; Mental health [elderly] ; Diagnosis ; Clinical surveys ; United States of America. |
| Annotation | 43 non-demented older people genotyped for the Apolipoprotein E (ApoE) e4 allele were neuropsychologically compared to 90 participants without a copy of the e4 allele. At baseline, the groups did not differ on age, education, gender, or global cognitive status. ApoE-e4 participants demonstrated significantly poorer mean performances on delayed recall, but no significant group differences emerged on attention, language, constructional skills, psychomotor speed, or executive function. Significantly more ApoE-e4 participants developed probable or questionable Alzheimer's disease (AD) compared with non-e4 participants, suggesting that the group differences resulted from a preponderance of pre-clinical AD cases within the e4 group and not from a direct influence of ApoE genotype or condition. Cox proportional hazards analysis, adjusted for age, years of education, and global cognitive status, revealed that ApoE-e4 allele status and measures of recall performance were significant and independent predictors of conversion to AD. Results support the importance of specific episodic memory changes and possession of the ApoE-e4 allele in the pre-clinical detection of AD. (RH). |
| Accession Number | CPA-990825220 A |
| Classmark | EA: D: LK7: 3G: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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