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Centre for Policy on Ageing | |
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| Comparative efficacy and safety of sertraline versus nortriptyline in major depression in patients 70 and older | | Author(s) | Sanford I Finkel, Ellen M Richter, Cathryn M Clary |
| Journal title | International Psychogeriatrics, vol 11, no 1, March 1999 |
| Pages | pp 85-100 |
| Keywords | Drugs ; Depression ; Over 70s ; Comparison ; Clinical surveys ; United States of America. |
| Annotation | Given the lack of studies examining antidepressant treatment of over 70s, a sub-group analysis was carried out with 76 outpatients meeting DSM-III criteria for major depression and minimum Hamilton Rating Scale (HAM-D) severity score of 18. Patients were randomised to 12 weeks of flexible dose treatment with setraline (50-150 mg) or nortriptyline (25-100 mg). Both treatments significantly improved depression as measured by the HAM-D and Clinical Global Impression (CGI) scales. At weeks 10, 12 and endpoint, setraline demonstrated a significantly greater reduction in depression severity compared to nortriptyline as measured by improvement on the 24 HAM-D. Setraline had a significantly more positive effect, when compared with nortriptyline, across almost all associated measures of cognitive function, energy, anxiety, and quality of life and was better tolerated than nortriptyline, with a lower attrition rate/side effect burden. The efficacy advantage of sertraline appeared to be even greater in this sub-group of older patients drawn from a larger treatment study of depression that included older people aged over 60. (RH). |
| Accession Number | CPA-990728219 A |
| Classmark | LLD: ENR: BBK: 48: 3G: 7T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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