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Centre for Policy on Ageing | |
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| Depressive illness, depressive symptomatology and regional cerebral blood flow in elderly people with sub-clinical cognitive impairment | | Author(s) | Karen Ritchie, Clare Gilham, Bernard Ledésert |
| Journal title | Age and Ageing, vol 28, no 4, July 1999 |
| Pages | pp 385-392 |
| Keywords | Depression ; Cognitive impairment ; Dementia ; Longitudinal surveys ; France. |
| Annotation | Depressive illness in dementia is often assumed to be a unitary clinical phenomenon. This study describes changes in patterns of depressive symptomatology with time, and associated changes in cerebral blood flow to the frontal and temporal regions. 397 French people from the Eugeria longitudinal study of cognitive ageing, aged 64 and over and with sub-clinical cognitive dysfunction, were observed over 3 years. 16% of them developed dementia during the study. The prevalence of depressive symptomatology was higher in this group than in the general population, especially in women, who also had higher recovery rates. A changing profile of depressive symptoms was found in depressed older people progressing to dementia, with fewer affective symptoms and increases in agitation and motor slowing. These changes were paralleled by by greater reductions in left temporal regional cerebral blood flow than in non-depressed subjects with Alzheimer's disease (AD). The results suggest two separate and interacting depressive syndromes whose differentiation may be important in the clinical management of dementia. (RH). |
| Accession Number | CPA-990715221 A |
| Classmark | ENR: E4: EA: 3J: 765 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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