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A method for assessing clinically relevant individual cognitive change in older adult populations
Author(s)Stephen M Sawrie, Daniel C Marson, Amy L Boothe
Journal titleThe Journals of Gerontology Series B: Psychological sciences and social sciences, vol 54B, no 2, March 1999
Pagespp P116-P124
KeywordsMental ageing ; Evaluation ; Methodology ; United States of America.
AnnotationThe evaluation of individual cognitive change has relied heavily on the raw change score, defined simply as the difference between follow-up and baseline scores. However, raw change scores are susceptible to the confounding effects of both regression to the mean and practice effect. The clinical relevance of raw change scores for the older adult is also obscured by normal, age-related cognitive change. The present study illustrates the use of a standardised regression-based (SRB) methodology to generate an alternative to the raw change score, the SRB change score. SRB change scores provide a standardised alternative to the raw change score, allowing the clinician to evaluate the magnitude of change on one or more variables along a common metric that controls for practice effect, regression-to-the-mean, and normal cognitive decline. Case data for Alzheimer's disease (AD), vascular dementia, and Pick's disease illustrate how SRB change scores can identify clinically relevant cognitive change in the individual older adult patient. (RH).
Accession NumberCPA-990430005 A
ClassmarkD6: 4C: 3D: 7T

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