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Centre for Policy on Ageing | |
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| Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia | | Author(s) | Alan J Sinclair, Antony J Bayer, Jo Johnston |
| Journal title | International Journal of Geriatric Psychiatry, vol 13, no 12, December 1998 |
| Pages | pp 840-845 |
| Keywords | Dementia ; Tissues ; Nervous systems ; Vitamins ; Cross sectional surveys ; Cardiff. |
| Annotation | Oxygen-free radicals and lipid hydroperoxides may have an aetiological role in lesion development in the central nervous system (CNS) of patients with Alzheimer's disease (AD) or with vascular dementia (VD). This Cardiff University Department of Geriatric Medicine study conducted a dietary assessment, and compared blood markers of oxidative stress by means of post-prandial venous blood samples obtained from: 25 subjects with probable AD (mean age 74.3; 10 F, 15 M;); 17 with probable VD (mean age 75.5; 5 F, 12 M); and 41 controls (mean age 73.4; 24 F, 17 M) for measurement of circulating lipid peroxide (LP), total antioxidant capacity (TAC), vitamin C (VitC) vitamin E (vitE) and beta-carotene (BC). Plasma levels of VitC were significantly lower in subjects with vascular dementia compared with controls, with no significant difference between controls and patients with AD. VitE levels were much lower in those with AD compared with controls. BC levels were similar in AD subjects and controls, but significantly elevated in those with VD. Those with AD or VD forms of dementia have a degree of disturbance in antioxidant balance predisposing to oxidative stress. This may be a potential therapeutic area for antioxidant supplement. (RH). |
| Accession Number | CPA-990209009 A |
| Classmark | EA: BKT: BKN: CFE: 3KB: 95A |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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