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Centre for Policy on Ageing | |
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| Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies | | Author(s) | Clive Holmes, Nigel Cairns, Peter Lantos |
| Journal title | The British Journal of Psychiatry, vol 174, January 1999 |
| Pages | pp 45-50 |
| Keywords | Dementia ; Diagnosis ; Evaluation ; Postmortems. |
| Annotation | Following the success of the the Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NNICDS-ADRDA) criteria for Alzheimer's disease (AD), groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria. The cases in this study - assessing whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate - represent the first 80 post-mortem subjects from the Camberwell Dementia Case Register. Mixed pathologies were common (33.8%). The high specificities obtained for the CDLB (criteria for dementia with Lewy bodies) and NINDS-AIREN (National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et del'Enseignement Neurosciences) criteria (1.00 and 0.95 respectively) were associated with low sensitivities (0.22 and 0.43 respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values. Thus, current clinical diagnostic criteria are good at detecting pathology per se, but not at detecting pure pathology.(RH). |
| Accession Number | CPA-990119003 A |
| Classmark | EA: LK7: 4C: JVP |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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