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Centre for Policy on Ageing | |
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| Are rates of ageing determined in utero? | | Author(s) | Avan Aihie Sayer, Cyrus Cooper, Jennifer R Evans |
| Journal title | Age and Ageing, vol 27, no 5, September 1998 |
| Pages | pp 579-583 |
| Keywords | Biological ageing ; Ageing process ; Health [elderly] ; Visual impairment ; Weight ; Skin problems ; Cross sectional surveys ; Hertfordshire. |
| Annotation | Epidemiological studies have shown that poor early growth is associated with cardiovascular and other degenerative diseases: undernutrition restricts early growth and permanently changes the body's structure and physiology. Whilst animal studies give many examples of nutritional programming and demonstrate the effects of undernutrition in utero, such effects have not been studied in man. To determine if poor early growth was associated with increased markers of ageing in later life, the authors traced 1428 men and women born in Hertfordshire between 1920 and 1930, for whom records of early weight were available. 824 (58%) were interviewed at home, of whom 717 (50%) attended clinic for eye examination, audiometry, grip strength measurement, skin thickness ultrasound and anthropometry. Lower weight at 1 year was associated with increased lens opacity score, higher hearing threshold, reduced grip strength and thinner skin. Visual acuity, macular degeneration and intraocular pressure were not related to early growth. Thus, the association between poor early growth and increased markers of ageing suggests that ageing may be programmed by events in early life. A potential mechanism is the impaired development of repair systems. (RH). |
| Accession Number | CPA-981119004 A |
| Classmark | BH: BG: CC: BR: 4X6: BLM: 3KB: 8HT |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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