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Centre for Policy on Ageing | |
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| Comorbidity in Alzheimer's disease | | Author(s) | Ladislav Volicer, Ann Hurley |
| Journal title | Journal of Mental Health and Aging, vol 3, no 1, Spring 1997 |
| Pages | pp 5-18 |
| Keywords | Dementia ; Diseases ; Assessment procedures for mental patients. |
| Annotation | The presence of comorbid conditions complicates both the design and interpretation of clinical trials involving people with Alzheimer's disease (AD). There are two types of comorbidity. First, random comorbidity - in which AD coexists with another disease by chance - affects clinical trials, because the other diseases may interfere with making a diagnosis, affect the result of therapeutic interventions, or alter the natural course of AD. The other type is epidemiological comorbidity, in which there is a relationship between prevalence of AD and other diseases. Clinical trials may control for comorbidity by either evaluating the influence of individual diseases, or by using a global index of comorbidity for each experimental subject. Although there are a number of methods for computing a comorbidity index, none of them was specifically designed for subjects with AD. The use of these methods is complicated, because some consider dementia as a comorbid condition, and others do not include comorbid conditions that are important for AD patients. However, the methods are a useful starting point in designing and investigating AD. (RH). |
| Accession Number | CPA-981020247 A |
| Classmark | EA: CJ: DA:4C |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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