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Effect of Tamoxifen on bone fractures in older nursing home residents
Author(s)Brenda Breuer, Sylvan Wallenstein, Richard Anderson
Journal titleJournal of the American Geriatrics Society, vol 46, no 8, August 1998
Pagespp 968-972
KeywordsOlder women ; Cancer ; Drugs ; Fractures ; Patients [nursing homes] ; United States of America.
AnnotationTamoxifen is a drug used in the treatment of breast cancer. This US study evaluated the association between Tamoxifen treatment and rate of bone fractures in 93,031 female nursing home residents, aged 65 years and over, comparing women who were receiving the drug with those who were not, over a one and a half-year period. Results showed that during that period, the fracture rates were 7.62% in women not treated with Tamoxifen, 3.20% in women receiving 10 mg daily, and 6.73% in women receiving 20 mg daily. The study concluded that standard treatment of 20 mg Tamoxifen daily offered no apparent protection against bone fractures in older nursing home residents, however, a daily 10 mg dose appeared to be effective. (AKM).
Accession NumberCPA-981002403 A
ClassmarkBD: CK: LLD: CUF: LHB:LF: 7T

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