| |
Centre for Policy on Ageing | |
 | |
|
Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study
— the Rotterdam study | | Author(s) | A Ott, A J C Slooter, A Hofman |
| Journal title | The Lancet, vol 351, no 9119, 20 June 1998 |
| Pages | pp 1840-1843 |
| Keywords | Tobacco smoking ; At risk ; Dementia ; Longitudinal surveys ; Netherlands. |
| Annotation | Previous studies have suggested a protective effect of smoking on Alzheimer's disease (AD), but most were case-control studies based on prevalent cases. The findings of prospective studies on the association between smoking and the risk of dementia are inconclusive. This article reports on the Rotterdam Study, a population-based follow-up study of 6,870 people aged 55 year and older who were initially free of dementia. Smoking history was taken at baseline; and during follow-up, all incident cases of dementia were recorded. Never smokers were used as the reference category to calculate relative risks of dementia and AD by Cox proportional hazards regression, after adjustment for age, sex, education, and alcohol intake. Also examined were modification of risk by age, sex, and the alipoprotein E (APOE) genotype. During mean follow-up of 2.1 years, 146 incident cases of dementia were detected, of which 105 were AD, with smokers having an increased risk, compared with never smokers. Smoking was a strong risk factor for AD in those without the APOE 4 allele, but had no effect on participants with this allele. Thus, in this study, smoking was associated with doubling of the risk of dementia and AD. (RH). |
| Accession Number | CPA-980828219 A |
| Classmark | ETT: CA3: EA: 3J: 76H * |
Data © Centre for Policy on Ageing |
|
| ...from the Ageinfo database published by Centre for Policy on Ageing. |
| |
|