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Centre for Policy on Ageing | |
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| Aspirin, anti-inflammatory drugs and risk of dementia | | Author(s) | A S Henderson, A F Jorm, H Christensen |
| Journal title | International Journal of Geriatric Psychiatry, vol 12, no 9, September 1997 |
| Pages | pp 926-930 |
| Keywords | Dementia ; Cognitive impairment ; At risk ; Drugs ; Longitudinal surveys ; Australia. |
| Annotation | A longitudinal study over 3.6 years of older people living in the community in Canberra, Australia, tested the hypothesis that aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) may prevent dementia or cognitive impairment. Cognitive functioning was measured using the Mini-Mental State Examination (MMSE), an episodic memory test, a test of mental speed, and the National Adult Reading Test. Dementia was assessed using the Canberra Interview for the Elderly. On cross-sectional data, those who had taken NSAIDs or aspirin performed no better on the cognitive tests after account had been taken of other confounding variables. There was no interaction with apolipoprotein E genotype (apoE). On longitudinal data, no difference was found between NSAID or aspirin users and controls, either in cognitive decline or incidence of dementia. The results do not support the hypothesis that aspirins or NSAIDs have a protective effect, but it remains possible that various sources of measurement error may have attenuated an effect of clinical significance from either type of drug. Conclusive evidence can only be obtained by a prospective trial. (RH). |
| Accession Number | CPA-980827268 A |
| Classmark | EA: E4: CA3: LLD: 3J: 7YA |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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