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Centre for Policy on Ageing | |
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Oxidative stress and advancing age
— results in healthy centenarians | | Author(s) | Giuseppe Paolisso, Maria Rosario Tagliamonte, Maria Rosaria Rizzo |
| Journal title | Journal of the American Geriatrics Society, vol 46, no 7, July 1998 |
| Pages | pp 833-838 |
| Keywords | Ageing process ; Biological ageing ; Nutrition ; Endocrine systems ; Centenarians ; Good Health ; Italy. |
| Annotation | Ageing and age-related degenerative diseases may induce changes that foster systemic anti-oxidant/pro-oxidant imbalance, which results in oxidative stress, In particular, major causes of disability in older people such as atherosclerosis, Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, diabetes mellitus and hypertension, are also considered free radical related diseases. 82 people volunteered for this Italian study: 30 under 50s; 30 aged 70-99; and 22 aged 100 years and over. Results indicated that centenarians have a degree of oxidative stress lower than aged subjects, but higher than adults. Differences in anti-oxidant defences (plasma vitamins E and C and reduced/oxidised glutathione ratio), fasting plasma glucose, and FFA (free fatty acid) concentrations and insulin resistance seem to contribute to the genesis of oxidative stress and to the differences between aged persons and centenarians. Differences in daily vegetable intake and in metabolic parameters might play a role. Further studies will need to investigate the role of genetic background on the degree of oxidative stress and the amount of anti-oxidant defences. (RH). |
| Accession Number | CPA-980819004 A |
| Classmark | BG: BH: CF: BKH: BBT: CD: 76V |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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