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Centre for Policy on Ageing | |
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| Population-based study of the prevalence and presentation of dementia in adults with Down's syndrome | | Author(s) | A J Holland, J Hon, F A Huppert |
| Journal title | The British Journal of Psychiatry, vol 172, June 1998 |
| Pages | pp 493-498 |
| Keywords | Cognitive impairment ; Dementia ; Memory and Reminiscence ; Mobility ; Self care capacity ; Middle aged ; Evaluation. |
| Annotation | The reported prevalence rates of dementia in people with Down's syndrome have differed considerably across studies. The purpose of this study was to examine the extent of clinical change with age using an established diagnostic instrument in an unbiased, population-based sample of older people with Down's syndrome. Using a modified version of the informant interview of the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX), changes in memory, personality, general functioning and daily living skills were assessed in 75 older people with Down's syndrome. Findings revealed that age-specific prevalence rates of dementia varied according to the diagnostic criteria used. Using CAMDEX criteria for Alzheimer's disease, prevalence rates increased from 3.4% to 10.3% to 40% in the 30-39, 40-49 and 50-59 age group, respectively. The study concluded that the age-related pattern of presentation differs from that seen in the general older population. However, age-specific prevalence rates of Alzheimer's disease were similar, but 30-40 years earlier in life. (AKM). |
| Accession Number | CPA-980709224 A |
| Classmark | E4: EA: DB: C4: CA: SE: 4C |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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