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Prognostic factors in very old demented adults
 — seven-year follow-up from a population-based survey in Stockholm
Author(s)Hedda Agüero-Torres, Laura Fratiglioni, Zhenchao Guo
Journal titleJournal of the American Geriatrics Society, vol 46, no 4, April 1998
Pagespp 444-452
KeywordsDementia ; Cognitive impairment ; Self care capacity ; Over 70s ; Longitudinal surveys ; Sweden.
AnnotationThis Swedish study looked at predictors of survival at 3- and 7-year follow-ups of people aged 75 and over, 133 with Alzheimer's disease (AD), 52 with vascular dementia ((VaD), and 38 with other types of dementia (OD), evaluated by Cox proportional hazard models. Progression was measured as the annual rate of change in Mini-Mental State Examination (MMSE) scores. Linear models evaluated predictors of progression. Older age, male gender, low education, comorbidity, and functional disability predicted shorter 7-year survival in the 223 cases. Other factors, including type of dementia, dementia severity, and duration of the disease were not significant. The average rate of cognitive decline in the mild to moderate demented subjects who survived 3 years was 2.4 MMSE points per year. Type of dementia (AD vs OD), higher baseline cognitive function, and greater functional disability predicted faster decline. Despite similar survival probability, predictors of death varied as a function of dementia type. Although there are methodological problems, it is possible to identify those with worse prognoses (shorter survival/faster cognitive decline). Other chronic conditions may also cause increased mortality in those with dementia. (RH).
Accession NumberCPA-980527002 A
ClassmarkEA: E4: CA: BBK: 3J: 76P

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