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P2 flash visual evoked response delay may be a marker of cognitive dysfunction in healthy elderly volunteers
Author(s)Norman C Moore, Robert L Vogel, Karen A Tucker
Journal titleInternational Psychogeriatrics, vol 8, no 4, Winter 1996
Pagespp 549-559
KeywordsCognitive processes ; Memory and Reminiscence ; Dementia ; Evaluation ; United States of America.
AnnotationIn an earlier study, 31 healthy older participants had normal, cognitive function as measured by the Mini-Mental State Examination (MMSE). In this study, 27 of the original sample returned for further memory testing using the Wechsler memory Scale-Revised (WMS-R). The P2 latency of the flash visual evoked response was positively correlated with age, but was not significantly related to gender. Nine of the twenty-seven subjects had a delayed P2, suggestive of dementia. Although unaware of any memory deficits, 5 of the 27 had WMS-R visual memory span percentile scores 1 or more standard deviations less than age-matched controls. Four of the five also had a significantly delayed P2 component. The findings suggest that a delayed P2 in supposedly healthy subjects is indicative of a visuo-spatial deficit which might be a precursor of dementia later. (AKM).
Accession NumberCPA-980303278 A
ClassmarkDA: DB: EA: 4C: 7T

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