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Centre for Policy on Ageing | |
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Mortality and temporal course of probable Alzheimer's disease
— a 5-year prospective study | | Author(s) | Barry Reisberg, Steven H Ferris, Emile H Franssen |
| Journal title | International Psychogeriatrics, vol 8, no 2, Summer 1996 |
| Pages | pp 291-311 |
| Keywords | Dementia ; Death ; Longitudinal surveys. |
| Annotation | Alzheimer's disease (AD) is associated with an an increased mortality in comparison with aged control populations. The relationship between the clinical and the temporal course of AD has not been well studied over significant intervals. 103 patients living in the community with probable AD (42 men, mean age 70.2 ± 8 years) were studied at baseline on demographic and clinical variables, including measures of global deterioration (GDS), mental status and cognition (e.g. Mini Mental State Examination, MMSE), and functional impairment (Functional Assessment Staging, FAST). Mortality in this sample appeared to be independent of the magnitude of severity of dementia. Individuals in all three severity groups died at similar rates. Change in clinical variables correlated significantly with time elapsed. Significant variance in temporal change (i.e. time elapsed) was accounted for by change in GDS and FAST. The results support previous estimates of mean duration of the GDS and FAST stages. For subjects with probable AD followed over approximately 5 years, clinical variables changed significantly over time in survivors. However, most of the temporal variance in the course of AD remains unexplained. (RH). |
| Accession Number | CPA-980303262 A |
| Classmark | EA: CW: 3J |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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