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Centre for Policy on Ageing | |
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| The Alzheimer's Disease Assessment Scale | | Author(s) | Richard C Mohs |
| Journal title | International Psychogeriatrics, vol 8, no 2, Summer 1996 |
| Pages | pp 195-203 |
| Keywords | Dementia ; Cognitive processes ; Evaluation ; Clinical surveys ; Longitudinal surveys. |
| Annotation | This article reviews longitudinal data collected from patients with Alzheimer's disease (AD) that are relevant to the design and interpretation of clinical treatment trials. Longitudinal data from patients tested with the Alzheimer's Disease Assessment Scale demonstrate that cognitive symptoms, including memory loss, dysphasia, and dyspraxia worsen relentlessly over time with the rate of change depending on baseline dementia severity. Non-cognitive symptoms, such as agitation, depressed mood, and psychosis, are episodic, do not necessarily worsen over time, and tend not to be highly correlated with one another. The reliability of cognitive change measures increases with follow-up duration, so that the likelihood of detecting drug effects on the rate of cognitive deterioration is greater with longer treatment trials. Functional measures of activities of daily living (ADLs) are difficult to standardise for AD patients, but are important for determining the overall clinical and economic impact of AD treatments. (RH). |
| Accession Number | CPA-980303254 A |
| Classmark | EA: DA: 4C: 3G: 3J |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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