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Exercise training and nutritional supplementation for physical frailty in very elderly people
Author(s)Maria A Fiatarone, Evelyn F O'Neill, Nancy Doyle Ryan
Journal titleThe New England Journal of Medicine, vol 330, no 25, 23 June 1994
Pagespp 1769-1775
KeywordsExercise ; Nutrition ; Vitamins ; Mobility ; Over 70s ; Nursing homes ; United States of America.
AnnotationAlthough disuse of skeletal muscle and undernutrition are often cited as potentially reversible causes of frailty in older people, the efficacy of interventions targeted at those deficits has not been examined. A randomised placebo-controlled trial compared progressive, resistance exercise training, multinutrient implementation, both interventions, and neither in 100 frail nursing home residents over a 10-week period. Mean age of 63 men and women was 87.1 (range 72 to 98). Muscle strength increased by 113±8% in those undergoing exercise training, as compared with 3±9% in the non-exercise group. Gait velocity increased by 11.8±3.8% in exercisers but declined 1±3.8% in non-exercisers. Exercisers' stair climbing power improved, as did level of spontaneous physical activity. The nutritional supplement had no effect on any primary outcome measure. Total energy intake was significantly increased only in those exercising subjects also receiving nutritional supplementation. High-intensity resistance exercise training is a feasible and effective means of counteracting muscle weakness and physical frailty in the very old. In contrast, multinutrient supplements without exercise does not reduce muscle weakness or frailty. (RH).
Accession NumberCPA-980108232 A
ClassmarkCEA: CF: CFE: C4: BBK: LHB: 7T *

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