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Learning and retention in preclinical and early Alzheimer's disease
Author(s)Ellen Grober, Claudia Kawas
Journal titlePsychology and Aging, vol 12, no 1, March 1997
Pagespp 183-188
KeywordsDementia ; Memory and Reminiscence ; Learning capacity ; Cognitive processes ; Evaluation.
AnnotationAccelerated forgetting has been proposed as the first sign in pre-clinical and early Alzheimer's disease (AD).The authors investigated learning and retention in participants who later developed AD with free and cued selective reminding (FCSR), a test which maximises learning by inducing deep semantic processing, and by controlling study and test conditions. AD patients in the pre-clinical stage recalled significantly fewer words than did matched control participants, indicating an impairment of learning. Nonetheless, patients' retention was identical to that of control participants, whose retention was still perfect. Thus, a retention deficit is not present in pre-clinical AD, when hallmark learning deficit can be documented. Detection of pre-clinical and very early AD may be best accomplished by using robust learning tests that control cognitive processing.
Accession NumberCPA-971120248 A
ClassmarkEA: DB: DE: DA: 4C

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