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Centre for Policy on Ageing | |
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Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype
— cross sectional population based study | | Author(s) | Johanna Kuusisto, Keijo Koivisto, Lena Mykkänen |
| Journal title | British Medical Journal, vol 315, no 7115, 25 October 1997 |
| Pages | pp 1045-1049 (BMJ Aging issue) |
| Keywords | Drugs ; Diabetes ; Dementia ; Diagnosis ; Correlation ; Cross sectional surveys ; Finland. |
| Annotation | The presence of features of the insulin resistance syndrome and diagnosis of Alzheimer's disease (AD) was examined in a study of 980 people aged 69 to 78 in eastern Finland. 46 (4.7%) subjects were classified as having probable or possible AD. In univariate analyses, apolipoprotein E4 phenotype, age, low level of education, low total cholesterol concentration, high systolic blood pressure, high fasting and 2 hour insulin concentrations, and abnormal glucose tolerance were significantly associated with AD. In multivariate analyses including apolipoprotein E4 phenotype, age, education, systolic blood pressure, total cholesterol concentration, fasting glucose concentration, E4 phenotype, age, education, total cholesterol, and insulin were significantly associated with AD. In 532 non-diabetic subjects without the e4 allele, hyperinsulinaemia was associated with an increased risk for AD. In contrast, in the 228 with the e4 allele, hyperinsulinaemia had no effect on the risk of disease. Features of the insulin resistance syndrome are associated with AD independently of apolipoprotein E4 phenotype. |
| Accession Number | CPA-971118406 A |
| Classmark | LLD: CPD: EA: LK7: 49: 3KB: 76L * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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