Centre for Policy on Ageing
 

 
You haven't heard the end of it
 — telomere loss may link human aging with cancer
Author(s)Jerry W Shay, Harold Werbin, Woodring E Wright
Journal titleCanadian Journal on Aging, vol 14, no 3, Fall 1995
Pagespp 511-524
KeywordsBiological ageing ; Cancer.
AnnotationThe molecular details of the relationship between cellular senescence and cancer are beginning to emerge. Since telomeres (the ends of the chromosomes) shorten progressively with each cell division, it has been proposed that telomere shortening is the clock that times cellular senescence. The re-expression of telomerase (the enzyme that maintains telomeres and prevents their shortening) occurs in most tumour cells and is probably a critical event in the formation and sustained growth of most cancers. (RH).
Accession NumberCPA-970821271 A
ClassmarkBH: CK

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