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Impact of physical illness on quality of life and antidepressant response in geriatric major depression
Author(s)Gary W Small, Martin Birkett, Barnett S Meyers
Journal titleJournal of the American Geriatrics Society, vol 44, no 10, October 1996
Pagespp 1220-1225
KeywordsDepression ; Chronic illness ; Diseases ; Drugs ; Quality of life ; United States of America.
AnnotationAs people get older, they are likely to suffer from chronic medical illnesses that can have a serious impact on their quality of life. This US study assessed the impact of physical illness on functional status and treatment outcome in 671 older depressed patients who participated in a clinical trial of fluoxetine (antidepressant). Findings showed that most patients reported physical illness. Greater numbers of baseline chronic illness indicated worse physical functioning, general health perceptions, and vitality and greater bodily pain and role limitations from physical problems. Historical physical illness was associated with worse physical functioning, vitality, general health perceptions, social functioning, and mental health. Although the number of chronic illnesses did not influence treatment response, historical physical illness was associated with greater response to the antidepressant, and lower placebo response. The findings suggest that both current and previous physical illness are associated with lower quality of life in geriatric depression, and that depressed older patients with chronic physical illness respond to antidepressants as well as those without such an illness. (AKM).
Accession NumberCPA-970812215 A
ClassmarkENR: CI: CJ: LLD: F:59: 7T

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