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Affective disturbances in Alzheimer's disease
Author(s)Catherine Bungener, Roland Jouvent, Christian Derouesné
Journal titleJournal of the American Geriatrics Society, vol 44, no 9, September 1996
Pagespp 1066-1072
KeywordsDementia ; Depression ; Anxiety ; Assessment procedures for mental patients ; France.
AnnotationThe objective of this French study was to assess depressive and anxious symptomatology in Alzheimer's disease (AD) patients, using both a categorical and a dimensional approach, and to describe specific emotional disturbances more precisely. The study used the Hamilton Depression Rating Scale (HDRS) , the Retardation Rating Scale (RRS) for depression, Tyrer and Covi scales for anxiety, and the Depressive Mood Scale (DMS) for emotional disturbances. The Mini-Mental State Examination (MMSE) and the Mattis Dementia Rating Scale assessed cognitive status. 118 consecutive AD outpatients with probable or possible AD were compared with 34 community dwelling healthy older controls and 20 inpatients meeting diagnostic criteria for depression. No AD patient met criteria for major depressive episode or generalised anxiety disorder. AD patients scored significantly higher than the control group but lower than the depressed group for depressive and anxious symptomatology. Affective changes were found frequently in AD patients, but no major affective disorder was found. The dimensional approach seems to be more appropriate than the categorical approach to describe the emotional disturbances in these patients. (RH).
Accession NumberCPA-970812207 A
ClassmarkEA: ENR: ENP: DA:4C: 765

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