Centre for Policy on Ageing
 

 

Site variability in a multisite geriatric depression trial
Author(s)Gary W Small, Lon S Schneider, S H Hamilton, Alexander Bystritsky
Journal titleInternational Journal of Geriatric Psychiatry, vol 11, no 12, December 1996
Pagespp 1089-1095
KeywordsDepression ; Geriatric out-patients clinics ; Drugs ; Evaluation ; Clinical surveys ; United States of America.
AnnotationThe authors studied differences in outcome and characteristics among 29 clinical sites of a multisite, double-blind antidepressant (fluoxetine) trial for geriatric depression. Results obtained suggest that individual practitioners may have vastly different clinical experiences on large, multisite trials for geriatric depression. Interrater reliability, subject selection, recruitment, inadequate or fixed dosing, few patients per site, brief study duration, heterogeneity of geriatric depression, financial incentive and characteristics of individual sites may contribute to response variability.
Accession NumberCPA-970421028 A
ClassmarkENR: L6G: LLD: 4C: 3G: 7T

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