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Centre for Policy on Ageing | |
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Trajectories of depressive and anxiety symptoms in older adults
— a 6-year prospective cohort study | | Author(s) | Sophie E Holmes, Irina Esterlis, Carolyn M Mazure |
| Journal title | International Journal of Geriatric Psychiatry, vol 33, no 2, February 2018 |
| Publisher | Wiley, February 2018 |
| Pages | pp 405-413 |
| Source | http://www.orangejournal.org |
| Keywords | Depression ; Anxiety ; Symptoms ; Ageing process ; Dementia ; At risk ; Evaluation. |
| Annotation | Depressive and anxiety symptoms are common in older adults, significantly affect quality of life and are risk factors for Alzheimer's disease. The present study sought to identify the determinants of predominant trajectories of depression and anxiety in cognitively normal older adults. 423 older adults recruited from the general community underwent positron emission tomography imaging, apolipoprotein and brain-derived neurotrophic factor genotyping, and cognitive testing at baseline and had follow-up assessments. All participants were cognitively normal and free of clinical depression at baseline. Latent growth mixture modelling was used to identify predominant trajectories of subthreshold depression and anxiety over six years. Binary logistic regression analysis was used to identify baseline predictors of symptomatic depressive and anxiety trajectories. Latent growth mixture modelling revealed two predominant trajectories of depression and anxiety: a chronically elevated trajectory and a low, stable symptom trajectory, with almost one in five participants falling into the elevated trajectory groups. Male sex, lower attentional function and carriage of the brain-derived neurotrophic factor Val66Met allele in women were associated with increased risk for chronically elevated depressive symptom trajectory. Carriage of the apolipoprotein epsilon 4 allele and lower executive function in women were associated with chronically elevated anxiety symptom trajectory. These results indicate distinct and sex-specific risk factors linked to depressive and anxiety trajectories which may help inform risk stratification and management of these symptoms in older adults at risk for Alzheimer's disease. (JL). |
| Accession Number | CPA-180302227 A |
| Classmark | ENR: ENP: CT: BG: EA: CA3: 4C |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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