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Longitudinal changes in global and domain specific cognitive function in the very-old
 — findings from the Newcastle 85+ Study
Author(s)Blossom C M Stephan, Graciela Muniz-Terrera, Antoneta Granic
Journal titleInternational Journal of Geriatric Psychiatry, vol 33, no 2, February 2018
PublisherWiley, February 2018
Pagespp 298-306
Sourcehttps://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.4743
KeywordsCognitive processes ; Mental ageing ; Cognitive impairment ; Dementia ; Octogenarians ; Longitudinal surveys ; Newcastle upon Tyne.
AnnotationAgeing is associated with changes in cognition in some, but not all domains. In young-old adults, defined as persons aged 65-84 years, baseline cognitive function has been shown to impact on cognitive trajectories. Whether similar patterns occur in the very-old, defined as persons aged 85 years and over, is not known. In this study longitudinal changes (five years' follow-up) in global and domain specific cognitive function including memory, attention and speed were investigated in 845 participants from the Newcastle 85+ Study. At baseline, participants were grouped using Mini-Mental State Examination cut-off scores and dementia status into the following: not impaired, mildly impaired or severely impaired/dementia groups. Only a limited number of cognitive measures showed significant decline in performance over time. Where observed, change generally occurred only in the severely impaired group. In the severely impaired group, small differences in baseline age were associated with poorer performance over time on most measures. Education was not protective against cognitive decline in any group. Overall findings showed that there are individuals who maintain a high level of cognitive function or only show mild impairments even into their ninth decade of life. This group of successful cognitive agers may provide insight for identifying predictors of cognitive integrity in later life. In individuals with severe impairment, cognitive performance shows significant decline over time, especially in measures of attention and speed. Further work to identify those individuals at highest risk of cognitive decline is necessary to implement early support and intervention strategies in this rapidly expanding age group. (JL).
Accession NumberCPA-180302223 A
ClassmarkDA: D6: E4: EA: BBM: 3J: 86A

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