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Centre for Policy on Ageing | |
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The risk of overweight/obesity in mid-life and late life for the development of dementia
— a systematic review and meta-analysis of longitudinal studies | | Author(s) | Emilio Pedditizi, Ruth Peters, Nigel Beckett |
| Journal title | Age and Ageing, vol 45, no 1, January 2016 |
| Publisher | Oxford University Press, January 2016 |
| Pages | pp 14-21 |
| Source | www.ageing.oxfordjournals.org |
| Keywords | Obesity ; Weight ; Dementia ; At risk ; Life span ; Longitudinal surveys. |
| Annotation | It has been suggested that being overweight or obese as a risk factor for incident dementia differs between midlife and later life. In this study the authors performed a systematic review and meta-analysis of the up-to-date current literature to assess the said hypothesis. Inclusion criteria included epidemiological longitudinal studies published up to September 2014, in participants without cognitive impairment based on evidence of cognitive assessment and aged 30 or over at baseline assessment with at least two years of follow-up. Various relevant databases were searched using combinations of the search terms: Dementia, Alzheimer Disease, Vascular Dementia, Multi-Infarct Dementia, Cognitive Decline, Cognitive Impairment, Mild Cognitive Impairment/Obesity, Overweight, Adiposity and Waist Circumference. Handsearching of all papers meeting the inclusion criteria was performed. A random-effects model was used for the meta-analysis. Of the 1,612 abstracts identified and reviewed, 21 completely met the inclusion criteria. Being obese below the age of 65 years had a positive association on incident dementia with a risk ratio, but the opposite was seen in those aged 65 and over. This systematic review and meta-analysis suggests a positive association between obesity in midlife and later dementia but the opposite in later life. Whether weight reduction in midlife reduces risk is worthy of further study. (JL). |
| Accession Number | CPA-160805200 A |
| Classmark | CSA: 4X6: EA: CA3: BG6: 3J |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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