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Centre for Policy on Ageing | |
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| A combined genetic and small molecule approach to studying the role of the p38/MK2 Stress Signalling Pathway in a human premature ageing syndrome | | Author(s) | Mark Bagley, Terry Davis, David Kipling, Joanna Latimer |
| Corporate Author | New Dynamics of Ageing Programme - NDA; Department of Sociological Studies, University of Sheffield |
| Publisher | New Dynamics of Ageing - NDA, Sheffield, 2014 |
| Pages | 8 pp (NDA Findings 35) |
| Source | NDA Research Programme, Department of Sociological Studies, University of Sheffield, Elmfield, Northumberland Road, Sheffield S10 2TU. www.newdynamics.group.shef.ac.uk Download at: http://newdynamics.group.shef.ac.uk/nda-findings-3... |
| Keywords | Biological ageing ; Cells ; Projects ; Research Reviews. |
| Annotation | This project studied human ageing biology, specifically a premature ageing condition, Werner syndrome (WS), which is associated with rapid cell ageing. The stressed and aged morphology of cells from individuals with WS, was corrected by treatment with inhibitors of MK2, a protein involved in stress-signalling, but these inhibitors had little effect on the morphology of normal cells. These findings outline how this research has increased our understanding of the biochemical triggers of ageing that operate in human dividing cells, and could lead to the postponement of chronic diseases of later life. (RH). |
| Accession Number | CPA-160624003 P |
| Classmark | BH: BKV: 3E: 3A:6KC * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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