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Centre for Policy on Ageing | |
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| Role of severity and gender in the association between late-life depression and all-cause mortality | | Author(s) | Hyun-Ghang Jeong, Jung Jae Lee, Seok Burn Lee |
| Journal title | International Psychogeriatrics, vol 25, no 4, April 2013 |
| Publisher | Cambridge University Press, April 2013 |
| Pages | pp 677-684 |
| Source | journals.cambridge.org/ipg |
| Keywords | Depression ; Death ; At risk ; Older men ; Older women ; Evaluation. |
| Annotation | Mortality associated with depression may be influenced by the severity of depression and gender. This study aimed to investigate the differential impacts on all-cause mortality of late-life depression by the type of depression (major depressive disorder, MDD; minor depressive disorder, MnDD; subsyndromal depression, SSD) and gender after adjusting for comorbid conditions in a random sample. 1,000 community-dwelling older individuals were enrolled. Standardised face-to-face clinical interviews, neurological examination and physical examination were conducted to diagnose depressive disorders and comorbid cognitive disorders. Depressive disorders were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria and SSD to study-specific operational criteria. Five-year survivals were compared between groups using Cox proportional hazards models. By the end of 2010, 174 subjects (17.4%) had died. Depressive disorder and its interaction term with gender were significant in predicting five-year survival. MDD was an independent risk factor for mortality in men whereas MnDD and SSD were not when other risk factors were adjusted. These findings show that MDD may directly confer the risk of mortality in older men whereas non-major depression may be just an indicator of increased mortality in both genders. (JL). |
| Accession Number | CPA-130315229 A |
| Classmark | ENR: CW: CA3: BC: BD: 4C |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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