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Centre for Policy on Ageing | |
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| Effects of education on the progression of early-versus late-stage mild cognitive impairment | | Author(s) | Byoung Seok Ye, Sang Wan Seo, Hanna Cho |
| Journal title | International Psychogeriatrics, vol 25, no 4, April 2013 |
| Publisher | Cambridge University Press, April 2013 |
| Pages | pp 597-606 |
| Source | journals.cambridge.org/ipg |
| Keywords | Cognitive impairment ; Dementia ; At risk ; Educational status [elderly] ; University education. |
| Annotation | Highly educated older individuals with normal cognition show lower incidence of Alzheimer's disease (AD) than poorly educated individuals, whereas longitudinal studies involving AD have reported that higher education is associated with more rapid cognitive decline. This study aimed to evaluate whether highly educated amnestic mild cognitive impairment (aMCI) participants showed more rapid cognitive decline than those with lower levels of education. 249 aMCI patients enrolled from 31 memory clinics using the standard assessment and diagnostic processes were followed with neuropsychological evaluation over 12-24 months. According to baseline performances on memory tests, participants were divided into early-stage aMCI and late-stage aMCI groups. Risk of AD conversion and changes in neuropsychological performances according to the level of education were evaluated. 62 patients converted to AD over a mean follow-up of 1.43 years. The risk of AD conversion was higher in late-stage aMCI than early-stage aMCI. Cox proportional hazard models showed that aMCI participants, and late-stage aMCI participants in particular, with higher levels of education had a higher risk of AD conversion than those with lower levels of education. Late-stage aMCI participants with higher education showed faster cognitive decline in language, memory and Clinical Dementia Rating Sum of Boxes (CDR-SOB) scores. On the contrary, early-stage aMCI participants with higher education showed slower cognitive decline in MMSE and CDR-SOB scores. These findings suggest that the protective effects of education against cognitive decline remain in early-stage aMCI and disappear in late-stage aMCI. (JL). |
| Accession Number | CPA-130315221 A |
| Classmark | E4: EA: CA3: F:V: V7M |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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