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Centre for Policy on Ageing | |
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Genetic and environmental factors in late onset dementia
— possible role for early parental death | | Author(s) | Lawrence J Whalley, Roger T Staff, Alison D Murray |
| Journal title | International Journal of Geriatric Psychiatry, vol 28, no 1, January 2013 |
| Publisher | Wiley-Blackwell, January 2013 |
| Pages | pp 75-81 |
| Source | www.orangejournal.org |
| Keywords | Dementia ; Octogenarians ; At risk ; Life span ; Physical environment ; Children ; Cognitive processes ; Parents ; Death. |
| Annotation | This study aimed to investigate three reports of a possible role of early parental death in late onset dementia. The authors tested a multivariate model of risk factors for late onset dementia that included established (female sex, a family history of dementia) and putative influences (vascular risk factors, years of full-time education, parental ages at death, and childhood IQ) on dementia risk. They examined contributions of early life and late life risk factors for dementia by using childhood social and family data and blood samples obtained at interview at age 78 years. In 1997-1999 281 subjects without dementia were recruited from a 1932 Scottish IQ survey of children born in 1921 who were later followed up in 2010 (at age 88). Binary logistic regression and Bayesian structural equation modelling were used to model dementia risk. Results showed that dementia risk was associated with increasing age from 77 to 88 years, female sex, death of either parent before age 11 and APOE e-4 genotype. A family history of dementia, childhood IQ, years of education and vascular risk factors did not contribute to the model. Multivariate models of the possible causes of late onset dementia confirm previous associations of dementia with female sex and APOE e-4 genotype and support earlier reports of a role for early parental death. (JL). |
| Accession Number | CPA-121214263 A |
| Classmark | EA: BBM: CA3: BG6: R: SBC: DA: SR: CW |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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