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Centre for Policy on Ageing | |
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| No increased mortality risk in older persons with unexplained anaemia | | Author(s) | Jorien M Willems, Wendy P J den Elzen, L Tom Vlasveld |
| Journal title | Age and Ageing, vol 41, no 4, July 2012 |
| Pages | pp 501-506 |
| Source | http://ageing.oxfordjournals.org/ http://www.bgs.org.uk/ |
| Keywords | Diseases of the blood ; Octogenarians ; Clinical surveys ; At risk ; Death ; Netherlands. |
| Annotation | In older persons, anaemia is associated with a number of unfavourable outcomes. In roughly 30% of cases the cause of the disease is unexplained. The present study aimed to assess the clinical differences between subjects with explained and unexplained anaemia and to investigate whether these subjects had different mortality patterns compared with subjects without anaemia. 491 persons aged 86 years and above took part in this Dutch programme, known as the the Leiden 85-plus study. The study population was divided in three groups: no anaemia, explained anaemia (iron deficiency, folate deficiency, vitamin B12 deficiency, signs of myelodysplastic syndrome or renal failure) and unexplained anaemia. Mortality risks were estimated with Cox-proportional hazard models. Haemoglobin levels were significantly lower in subjects with explained anaemia than in subjects with unexplained anaemia. An increased risk for mortality was observed in subjects with explained anaemia but not in subjects with unexplained anaemia. Adjusted analyses (sex, co-morbidity, MMSE, institutionalised and smoking) did not change the observed associations for both explained and unexplained anaemic subjects. In conclusion, older subjects with unexplained anaemia had similar survival rates compared with non-anaemic subjects. Increased mortality risks were observed in subjects with explained anaemia compared with non-anaemic subjects. (JL). |
| Accession Number | CPA-120814009 A |
| Classmark | CQT: BBM: 3G: CA3: CW: 76H |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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