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Centre for Policy on Ageing | |
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Clinical characteristics and mortality risk in relation to obstructive and central sleep apnoea in community-dwelling elderly individuals
— a 7-year follow-up | | Author(s) | Peter Johansson, Urban Alehagen, Eva Swanborg |
| Journal title | Age and Ageing, vol 41, no 4, July 2012 |
| Pages | pp 468-474 |
| Source | http://ageing.oxfordjournals.org/ http://www.bgs.org.uk/ |
| Keywords | Sleep disorders ; Respiratory tract diseases ; Cardiovascular diseases ; Heart disease ; Stroke ; Death ; At risk. |
| Annotation | Little is known about demographic and clinical characteristics associated with sleep-disordered breathing (SDB) and obstructive sleep apnoea (OSA) or central sleep apnoea (CSA) in community-dwelling older people. In the present study the authors investigated the association between these disorders and cardiovascular (CV) and all-cause mortality. 331 community-dwelling older people aged 71-87 years underwent a clinical examination and one-night polygraphic recordings in their homes. Mortality data were collected after seven years. Results showed that 55% of participants had SDB, 38% had OSA and 17% had CSA. Compared with those with no SDB and OSA, more participants with CSA had a left ventricular ejection fraction (LVEF), ischaemic heart disease (IHD) and transient ischaemic attack (TIA) or stroke. There was no difference in the rate of IHD and TIA/stroke between OSA and no SDB, but more LVEF was found in those with OSA. CSA significantly increased the risk for all-cause and CV mortality by more than double. After adjustments for CV disease, diabetes and the biomarker NT-pro-brain natriuretic peptide CSA associations to all-cause mortality and CV mortality lost significance. The authors conclude that OSA in persons aged over 75 years does not appear to be associated with cardiovascular disease (CVD) or mortality, whereas CSA might be a pathological marker of CVD and impaired systolic function associated with higher mortality. (JL). |
| Accession Number | CPA-120814004 A |
| Classmark | CTS: CN: CQ: CQH: CQA: CW: CA3 |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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