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Centre for Policy on Ageing | |
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Antidepressant use and risk of adverse outcomes in older people
— population based cohort study | | Author(s) | Carol Coupland, Paula Dhiman, Richard Morris |
| Journal title | British Medical Journal, vol 343, no 7819, 13 August 2011 |
| Pages | p 354 |
| Source | www.bmj.com BMJ2011;343;d4551 |
| Keywords | Depression ; Drugs ; Usage [services] ; At risk ; Longitudinal surveys. |
| Annotation | Comparatively little is known about the safety of antidepressant drugs in older people. Use of selective serotonin reuptake inhibitors (SSRIs) or drugs in the group of other antidepressants may be associated with an increased risk of some adverse outcomes compared with other tricyclic antidepressants in older people. This is a summary of a study published on bmj.com based on data for 60,746 patients diagnosed as having depression aged 65 to 100 from the QResearch primary care database followed for a mean of 5 years. 54,038 of these patients (89%) received at least one prescription for an antidepressant drug during follow-up. SSRIs were associated with the highest risk of falls and hypnonatremia. The group of other antidepressants was associated with the highest risks of all cause mortality, attempted suicide or self-harm, stroke or transient ischaemic attack (TIA), fracture, and epilepsy or seizure. (RH). |
| Accession Number | CPA-111117103 A |
| Classmark | ENR: LLD: QLD: CA3: 3J * |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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