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Centre for Policy on Ageing | |
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Longitudinal neuroimaging correlates of subjective memory impairment
— 4-year prospective community study | | Author(s) | Robert Stewart, Ophelia Godin, Fabrice Crivello |
| Journal title | British Journal of Psychiatry, vol 198, no 3, March 2011 |
| Pages | pp 199-205 |
| Source | http://bjp.rcpsych.org |
| Keywords | Memory disorders ; Biological ageing ; Evaluation ; Longitudinal surveys. |
| Annotation | Complaints about memory are common in older people but their relationship with underlying brain changes is controversial. The purpose of this study was to investigate the relationship between subjective memory impairment and previous or subsequent changes in white matter lesions and brain volumes. In a community cohort study of 1336 people without dementia, four-year changes in brain magnetic resonance imaging measures were investigated as correlates of subjective memory impairment at baseline and follow-up. Subjective memory impairment at baseline was associated with subsequent change in hippocampal volume and at follow-up impairment was associated with previous change in hippocampal, cerebrospinal fluid and grey matter volume and with subcortical white matter lesion increases. The authors conclude that complaints of poor memory by older people, particularly when new, may be a realistic subjective appraisal of recent brain changes independent of observed cognitive decline. (JL). |
| Accession Number | CPA-111115007 A |
| Classmark | EH: BH: 4C: 3J |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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