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Centre for Policy on Ageing | |
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| Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment | | Author(s) | Damien Gallagher, Robert Coen, Dana Kilroy |
| Journal title | International Journal of Geriatric Psychiatry, vol 26, no 2, February 2011 |
| Pages | pp 166-172 |
| Source | http://www.interscience.wiley.com/journal/gps |
| Keywords | Cognitive impairment ; Mental disorder ; Anxiety ; Behaviour disorders ; Dementia ; Clinical surveys. |
| Annotation | The objective of this study was to determine which symptoms among a range of neuropsychiatric symptoms known to occur in patients with mild cognitive impairment (MCI) are predictive of later conversion to Alzheimer's disease (AD). The research also looked at whether those symptoms track existing measures of declining cognitive and functional status or may be considered distinct and sensitive biomarkers of evolving Alzheimer's pathology. 161 patients with MCI were identified from consecutive referrals to a memory clinic. 76% of all patients had at least one neuropsychiatric symptom at baseline of which anxiety, affective disturbance and aggression were the most common. Increasing symptom frequency was observed with increasing clinical severity. Anticipatory anxiety and activity disturbances were significantly associated with earlier conversion to AD although this association did not remain significant following adjustment for cognitive status at baseline. In conclusion, neuropsychiatric symptoms and anxiety symptoms in particular are common in patients with MCI. In this sample anxiety for upcoming events and purposeless activity frequently co-occurred and were significant clinical predictors of early conversion to AD. (JL). |
| Accession Number | CPA-110815004 A |
| Classmark | E4: E: ENP: EP: EA: 3G |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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