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Centre for Policy on Ageing | |
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| A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians' relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity | | Author(s) | Andrea Corsonello, Alberto Montesanto, Maurizio Beradelli |
| Journal title | Age and Ageing, vol 39, no 6, November 2010 |
| Pages | pp 723-727 |
| Source | http://www.ageing.oxfordjournals.org http://www.bgs.org.uk doi: 10.1093/ageing/afq116 |
| Annotation | Several studies suggest that a decreased thyroid activity might be favourable in oldest-old subjects and that subclinical thyroid hyperfunction may be detrimental. Objectives of this research was to verify whether declining levels of circulating thyroid hormones may contribute to longevity. Design of the study involved a cross-sectional observational study. All subjects were born in Calabria (southern Italy) and their ancestry in the region was ascertained up to the grandparents. The subjects were six hundred and four home-dwelling subjects (301 females, 303 males), divided into three groups: 278 individuals 60-85 years old; 179 children or nieces/nephews of centenarians who are 60-85 years old; 147 individuals older than 85 years. Thyroid function parameters were measured in the frame of a comprehensive geriatric assessment. Results: FT3 and FT4 levels were negatively associated with age. Lower levels of FT3, FT4 and TSH were found in centenarians' children and nieces/nephews with respect to age-matched controls. Indeed, being a relative of centenarians qualified as an independent correlate of thyroid parameters. Age-related subtle thyroid hypofunction (either due to a familial component or due to a reset of the thyroid function occurring between the sixth and the eighth decade of life) appears to be related to longevity. (KJ) |
| Accession Number | CPA-101124214 A |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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