| |
Centre for Policy on Ageing | |
 | |
|
| Executive functioning in Alzheimer's disease and vascular dementia | | Author(s) | B McGuinness, S L Barrett, D Craig |
| Journal title | International Journal of Geriatric Psychiatry, vol 25, no 6, June 2010 |
| Pages | pp 562-568 |
| Source | http://www.interscience.wiley.com/journal/gps DOI: 10.1002/gps.2375 |
| Keywords | Cognitive processes ; Mental speed ; Learning capacity ; Dementia ; Performance. |
| Annotation | The performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of executive functioning and working memory were compared. 76 patients with AD and 46 with VaD were recruited from a memory clinic along with 28 dementia-free participants. They underwent specific tests of working memory from the Cognitive Drug Research (CDR) battery and pen and paper tests of executive function including CLOX 1 & 2, EXIT25 and a test of verbal fluency (COWAT). All patients had a CT brain scan which was independently scored for white matter change or ischaemia. The AD and VaD groups were significantly impaired on all measures of working memory and executive functioning compared to the disease free group. There were no significant differences between the AD and VaD groups on any measure. Z-scores confirmed the pattern of impairment in executive functioning and working memory was largely equivalent in both patient groups. Small to moderate correlations were seen between the MMSE and the neurocognitive scores in both patient groups and the pattern of correlations was also very similar in both patient groups. This study demonstrates sizeable executive functioning and working memory impairments in patients with mild-moderate AD and VaD but no significant differences between the disease groups. (RH). |
| Accession Number | CPA-1008272298 A |
| Classmark | DA: DG: DE: EA: 5H |
Data © Centre for Policy on Ageing |
|
| ...from the Ageinfo database published by Centre for Policy on Ageing. |
| |
|