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Centre for Policy on Ageing | |
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Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension
— data from the Hypertension in the Very Elderly Trial (HYVET) | | Author(s) | Ruth Peters, Elisabete Pinto, Nigel Beckett |
| Journal title | Age and Ageing, vol 39, no 4, July 2010 |
| Pages | pp 439-444 |
| Source | http://www.ageing.oxfordjournals.org http://www.bgs.org.uk doi:10.1093/ageing/afq042 |
| Keywords | Depression ; Cardiovascular diseases ; Dementia ; Death rate [statistics] ; Correlation ; Longitudinal surveys. |
| Annotation | Depression is common in older people and may be associated with increased cardiovascular risk and incident dementia. Participants in the Hypertension in the Very Elderly Trial (HYVET) completed a depression screening instrument, the Geriatric Depression Score (GDS), at baseline and annually. The authors examined the association of GDS score with incident stroke, mortality and dementia using Cox proportional hazards models (hazard ratios, HR and 95% confidence intervals, CI) adjusted for treatment group and other potential confounders. Results are from 2,656 HYVET participants who completed the GDS. The mean follow-up was 2.1 years. Each additional GDS point at baseline gave rise to a significantly increased risk of fatal and non-fatal cardiovascular events, all-cause mortality and dementia. There was a strong association between baseline depression scores and later fatal and non-fatal cardiovascular endpoints over a mean follow-up of 2 years in a hypertensive very elderly group. The mechanism of this association warrants further study. (KJ/RH). |
| Accession Number | CPA-100809210 A |
| Classmark | ENR: CQ: EA: S5: 49: 3J |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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