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Bevacizumab for neovascular age related macular degeneration (ABC Trial)
 — multicentre randomised double masked study
Author(s)Adnan Tufail, Praveen J Patel, Catherine Egan
Journal titleBritish Medical Journal, vol 340, no 7761, 26 June 2010
Pagesp 1398
Sourcewww.bmj.com BMJ2010;340:c2459
KeywordsVisual impairment ; Preventative medicine ; Drugs ; Clinical surveys.
AnnotationAre intravitreous bevacizumab injections better than standard care at improving vision in patients with neovascular age related macular degeneration (AMD)? This summary of a paper published on bmj.com reports on 131 patients age 50+ (mean age 81) randomised to two intervention groups: 65 eyes of 65 patients to bevacizumab 1.25mg intravitreously and 66 eyes of 66 patients to standard care (pregaptanib sodium, venterporfin, or sham). This study provides the first level 1 evidence supporting use of intravitreous bevacizumab every 6 weeks, resulting in a reduction in hospital visits by a third over conventional monthly dosing while maintaining improvement in vision. (RH).
Accession NumberCPA-100630211 A
ClassmarkBR: LK2: LLD: 3G *

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