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APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
— 10 years of incidence in the MRC CFA Study |
| Author(s) | H A D Keage, F E Matthews, A Yip |
| Journal title | Age and Ageing, vol 39, no 1, January 2010 |
| Pages | pp 104-111 |
| Source | http://www.ageing.oxfordjournals.org http://www.bgs.org.uk doi:10.1093/ageing/afp210 |
| Keywords | Dementia ; At risk ; Longitudinal surveys ; Cambridgeshire ; Gwynedd ; Newcastle upon Tyne ; Nottingham. |
| Annotation | Dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. The authors concentrate on incident dementia risk over 10 years. Participants come from MRC CFAS, a multi-centre longitudinal population-based study of ageing in England and Wales. Three follow-up waves of data collection were used: 2, 6 and 10 years. Logistic regressions were undertaken to investigate associations between APOE (n = 955) and ACE (n = 856) alleles/genotypes and incident dementia. Two types of control groups were used: non-demented and highly functioning non-demented. Results were back-weighted. The effects of ACE alleles/genotypes on incident dementia risk were small. In conclusion, APOE but not ACE is associated with late-onset incident dementia in the population. Using longer term follow-up with proper adjustment for attrition and incident cases increases estimates of risk. (KJ/RH). |
| Accession Number | CPA-100421207 A |
| Classmark | EA: CA3: 3J: 8C: 98: 86A: 8NTF |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |