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Centre for Policy on Ageing | |
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| Treatment of epilepsy in postmenopausal women | | Author(s) | Kristine S Ziemba, Katherine H Noe |
| Journal title | Aging Health, vol 6, no 1, February 2010 |
| Pages | pp 87-96 |
| Source | http://www.futuremedicine.com doi:10.2217/ahe.09.88 |
| Keywords | Older women ; Epilepsy ; Menopause ; Therapeutics ; Drugs. |
| Annotation | Epidemiological evidence for the increased incidence of epilepsy in older patients suggests that with global ageing of the population, there is likely to be a growing need for healthcare workers to manage seizures in older women. There has been relatively little scientific investigation into the unique concerns of postmenopausal woman with epilepsy. There is some evidence that women may experience increased seizure activity during the menopausal transition owing to the effects of oestrogen and progesterone on neuronal excitability. During perimenopause and menopause, use of hormone-replacement therapy (HRT) can also worsen seizure control. Menopausal women are particularly vulnerable to osteoporosis and fragility fractures, both of which demonstrate increased risk following exposure to anti-epileptic drugs. Optimisation of epilepsy therapy to avoid both seizures and falls caused by anti-epileptic drug-induced imbalance is crucial in order to minimise fracture risk in this group of women. Older patients are more susceptible to adverse medication side effects owing to drug interactions and the physiologic changes of ageing that result in altered drug pharmacokinetics. (KJ/RH). |
| Accession Number | CPA-100331220 A |
| Classmark | BD: E9: CC:BD: LL: LLD |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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