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Centre for Policy on Ageing | |
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| Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive tests | | Author(s) | Sebastian Palmqvist, Oskar Hansson, Lennart Minthon |
| Journal title | International Journal of Geriatric Psychiatry, vol 24, no 12, December 2009 |
| Pages | pp 1405-1412 |
| Source | http://www.interscience.wiley.com/journal/gps |
| Keywords | Dementia ; Diagnosis ; Cognitive processes ; Evaluation. |
| Annotation | Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, but it is often under-diagnosed and mistaken for Alzheimer's disease (AD) with sometimes lethal consequences. Over 35 studies have established the differences between DLB and AD in neuropsychological tests, but none have provided easy interpretations of common tests suitable for the clinician. The aim of this study was to suggest practical interpretations of the Mini-Mental State Examination (MMSE), clock drawing, and cube-copying to identify DLB and differentiate it from AD. Thirty-three DLB patients were matched according to gender, MMSE, and age with 66 AD patients. The median MMSE score was 24. Easy interpretations of the tests, including the MMSE orientation sub-score, were sought. The identified criteria to separate DLB from AD were: (1) the MMSE orientation score x3 is equal to or greater than the total MMSE score, (2) an impaired clock drawing, and (3) a non-3D cube-copying. If (1) was fulfilled, the sensitivity and specificity were 100 and 57% in patients with MMSE 21-27. If (1) and (2) were fulfilled in patients with MMSE 21-27, the sensitivity and specificity were 93 and 70%. If at least two of the three criteria were fulfilled, the sensitivity was 85%, and the specificity 75% regardless of MMSE score. Thus, if the orientation score x3 is equal to or greater than the total MMSE score together with an impaired clock drawing and possibly a non-3D cube-copying, the patient should be thoroughly investigated according to the DLB consensus criteria. (KJ/RH). |
| Accession Number | CPA-100109227 A |
| Classmark | EA: LK7: DA: 4C |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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