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Centre for Policy on Ageing | |
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| Morphometric analysis of neuronal and glial cell pathology in the dorsolateral prefrontal cortex in late-life depression | | Author(s) | Ahmad Khundakar, Christopher Morris, Arthur Oakley |
| Journal title | British Journal of Psychiatry, vol 195, no 2, August 2009 |
| Pages | pp 163-169 |
| Source | http://bjp.rcpsych.org |
| Keywords | Depression ; Cerebrovascular diseases ; Tissues ; Clinical surveys. |
| Annotation | Late-life depression has been associated with cerebrovascular disease and especially with ischaemic white matter hyperintensities on magnetic resonance imaging (MRI). Neuroimaging and morphometric studies have identified abnormalities in the dorsolateral prefrontal cortex. The aim of this study was to examine glial and neuronal density and neuronal volume in the dorsolateral prefrontal cortex in late-life major depression. The disector and nucleator methods were used to estimate neuronal density and volume and glial density of cells in the dorsolateral prefrontal cortex in a post-mortem study of 17 individuals with late-life major depression and 10 age-matched controls. The authors found a reduction in the volume of pyramidal neurones in the whole cortex, which was also present in layer 3 and more markedly in layer 5. There were no comparable changes in non-pyramidal neurones and no glial differences. Overall, the authors found a decrease in pyramidal neuronal size in the dorsolateral prefrontal cortex in late-life depression. (KJ/RH). |
| Accession Number | CPA-090914217 A |
| Classmark | ENR: CQ5: BKT: 3G |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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