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Centre for Policy on Ageing | |
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Cognitive deficits in middle-aged and older adults with bipolar disorder and cognitive complaints
— comparison with mild cognitive impairment | | Author(s) | Dina Silva, Isabel Santana, Frederico Simoes do Couto |
| Journal title | International Journal of Geriatric Psychiatry, vol 24, no 6, June 2009 |
| Pages | pp 624-631 |
| Source | http://www.interscience.wiley.com/journal/gps |
| Keywords | Schizophrenia ; Cognitive impairment ; Middle aged ; Older people ; Comparison ; Portugal. |
| Annotation | The main objective of this Portuguese study is to characterize the cognitive deficits of middle-aged and older patients with bipolar disorder (BD) and compare them with the common age-related cognitive deficits observed in Mild Cognitive Impairment (MCI). For this retrospective study, a systematic search for all cases of BD patients submitted to a neuropsychological assessment from 1999-2007, at participant institutions, was performed, and cases were matched (1:2) by gender and age to a sample of MCI subjects. A total sample of 135 patients, 45 patients with the diagnosis of BD, clinically stable, mean age of 63.8, and 90 patients with the diagnosis of MCI, mean age of 64.2, was studied. Patients with MCI were more impaired in verbal memory, whereas BD patients showed more deficits in attention, motor initiative, calculation and verbal abstraction. Interestingly, discriminant analysis classified about half of the BD group as belonging to the MCI group. This BD subgroup showed deficits in episodic memory similar to MCI patients. Patients with BD and patients with MCI have distinct profiles of cognitive impairment. A subgroup of BD patients with recent cognitive complaints may actually suffer from concomitant incipient MCI, and this finding may have diagnostic and therapeutic implications. (KJ/RH). |
| Accession Number | CPA-090824207 A |
| Classmark | ELK: E4: SE: B: 48: 76T |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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